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Article

Cdk7 is essential for mitosis and for in vivo Cdk-activating kinase activity.

Genes & development - 1 Feb 1998

Larochelle S, Pandur J, Fisher R P, Salz H K, Suter B

Abstract excerpt

Cdk7 has been shown previously to be able to phosphorylate and activate many different Cdks in vitro. However, conclusive evidence that Cdk7 acts as a Cdk-activating kinase (CAK) in vivo has remained elusive. Adding to the controversy is the fact that in the budding yeast Saccharomyces cerevisiae, CAK activity is provided by the CAK1/Civ1 protein, which is unrelated to Cdk7. Furthermore Kin28, the budding yeast...

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Identifiers

PMID: 9450931
DOI: 10.1101/gad.12.3.370
PMCID: PMC316490

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