Article
Cdk7 is essential for mitosis and for in vivo Cdk-activating kinase activity.
Genes & development - 1 Feb 1998
Larochelle S, Pandur J, Fisher R P, Salz H K, Suter B
Abstract excerpt
Cdk7 has been shown previously to be able to phosphorylate and activate many different Cdks in vitro. However, conclusive evidence that Cdk7 acts as a Cdk-activating kinase (CAK) in vivo has remained elusive. Adding to the controversy is the fact that in the budding yeast Saccharomyces cerevisiae...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- CDC2 Protein Kinase
- Cell Division
- Chromosome Mapping
- Cyclin-Dependent Kinases
- Cyclins
- DNA
- Drosophila melanogaster
- Embryo, Nonmammalian
- Genes, Insect
- Mitosis
- Molecular Sequence Data
- Mutation
- Protein Serine-Threonine Kinases
- Sequence Homology, Amino Acid
- Temperature