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Article

Biophysical characterization of structural properties and folding of interleukin-1 receptor antagonist.

Journal of molecular biology - 11 May 2007

Latypov Ramil F, Harvey Timothy S, Liu Dingjiang, Bondarenko Pavel V, Kohno Tadahiko, Fachini Roger A, Rosenfeld Robert D, Ketchem Randal R, Brems David N, Raibekas Andrei A

Abstract excerpt

Structural properties and folding of interleukin-1 receptor antagonist (IL-1ra), a therapeutically important cytokine with a symmetric beta-trefoil topology, are characterized using optical spectroscopy, high-resolution NMR, and size-exclusion chromatography. Spectral contributions of two tryptophan residues, Trp17 and Trp120, present in the wild-type protein, have been determined from mutational analysis. Trp17...

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Identifiers

PMID: 17391700
DOI: 10.1016/j.jmb.2007.02.031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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