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Article

Altered backbone and side-chain interactions result in route heterogeneity during the folding of interleukin-1β (IL-1β).

Biophysical journal - 20 Aug 2013

Capraro Dominique T, Lammert Heiko, Heidary David K, Roy Melinda, Gross Larry A, Onuchic José N, Jennings Patricia A

Abstract excerpt

Deletion of the β-bulge trigger-loop results in both a switch in the preferred folding route, from the functional loop packing folding route to barrel closure, as well as conversion of the agonist activity of IL-1β into antagonist activity. Conversely, circular permutations of IL-1β conserve the...

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Identifiers

PMID: 23972849
DOI: 10.1016/j.bpj.2013.06.019
PMCID: PMC3752112

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23972849-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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