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Article

Acid-induced molten globule state of a fully active mutant of human interleukin-6.

Biochemistry - 3 Sept 1996

De Filippis V, de Laureto P P, Toniutti N, Fontana A

Abstract excerpt

Interleukin-6 (IL-6), a four-helix bundle protein, is a multifunctional cytokine which plays an important role in the regulation of the immune system, hematopoiesis, and inflammatory response, as well as in the pathogenesis of multiple myeloma. We have previously shown that a single-disulfide variant of human IL-6, lacking 22 N-terminal amino acids and the disulfide bond connecting Cys-45 and Cys-51 in the...

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Identifiers

PMID: 8784206
DOI: 10.1021/bi9604587

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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