Article
Acid-induced molten globule state of a fully active mutant of human interleukin-6.
Biochemistry - 3 Sept 1996
De Filippis V, de Laureto P P, Toniutti N, Fontana A
Abstract excerpt
Interleukin-6 (IL-6), a four-helix bundle protein, is a multifunctional cytokine which plays an important role in the regulation of the immune system, hematopoiesis, and inflammatory response, as well as in the pathogenesis of multiple myeloma. We have previously shown that a single-disulfide var...
Topics
- Amino Acid Sequence
- Anilino Naphthalenesulfonates
- Circular Dichroism
- Endopeptidases
- Fluorescent Dyes
- Humans
- Hydrogen-Ion Concentration
- Interleukin-6
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Protein Binding
- Protein Conformation
- Protein Denaturation
- Protein Folding
- Protein Structure, Tertiary
- Sequence Deletion
- Spectrometry, Fluorescence