Roles of histidine 31 and tryptophan 34 in the structure, self-association, and folding of murine interleukin-6.

doi:10.1021/bi962939w

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Article

Roles of histidine 31 and tryptophan 34 in the structure, self-association, and folding of murine interleukin-6.

Biochemistry - 20 May 1997

Matthews J M, Ward L D, Hammacher A, Norton R S, Simpson R J

Abstract excerpt

Interleukin-6 (IL-6) is a multifunctional cytokine which is involved in a broad spectrum of activities such as immune defense, hematopoiesis, and the acute phase response, as well as in the pathogenesis of multiple myeloma. A series of murine IL-6 (mIL-6) mutants, H31A, W34A, and H31A/W34A, were...

Topics

Amino Acid Sequence
Animals
Biological Assay
Circular Dichroism
Guanidine
Guanidines
Histidine
Hydrogen-Ion Concentration
Interleukin-6
Magnetic Resonance Spectroscopy
Mice
Models, Chemical

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Molecular

Molecular Sequence Data

Mutation

Protein Conformation

Protein Denaturation

Protein Folding

Source

Open in PubMed

Identifiers

PMID: 9166791
DOI: 10.1021/bi962939w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9166791-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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