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Article

Roles of histidine 31 and tryptophan 34 in the structure, self-association, and folding of murine interleukin-6.

Biochemistry - 20 May 1997

Matthews J M, Ward L D, Hammacher A, Norton R S, Simpson R J

Abstract excerpt

Interleukin-6 (IL-6) is a multifunctional cytokine which is involved in a broad spectrum of activities such as immune defense, hematopoiesis, and the acute phase response, as well as in the pathogenesis of multiple myeloma. A series of murine IL-6 (mIL-6) mutants, H31A, W34A, and H31A/W34A, were constructed to investigate the roles of His31 and Trp34 in the structure, conformational stability, time-dependent...

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PMID: 9166791
DOI: 10.1021/bi962939w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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