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Article

Refined crystal structure of the interleukin-1 receptor antagonist. Presence of a disulfide link and a cis-proline.

European journal of biochemistry - 1 Feb 1995

Schreuder H A, Rondeau J M, Tardif C, Soffientini A, Sarubbi E, Akeson A, Bowlin T L, Yanofsky S, Barrett R W

Abstract excerpt

Interleukin-1 (IL-1) molecules are cytokines involved in the acute-phase response against infection and injury. Three naturally occurring IL-1 molecules are known, two agonists: IL-1 alpha and IL-1 beta, and one antagonist, the IL-1 receptor antagonist (IL-1ra). Although IL-1 action protects the organism by enhancing the response to pathogens, its overproduction can lead to pathology and has been implicated in...

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PMID: 7867645
DOI: 10.1111/j.1432-1033.1995.tb20209.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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