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Article

Serum osteopontin, an enhancer of tumor metastasis to bone, promotes B16 melanoma cell migration.

Journal of cellular biochemistry - 1 Jul 2007

Hayashi Chikako, Rittling Susan, Hayata Tadayoshi, Amagasa Teruo, Denhardt David, Ezura Yoichi, Nakashima Kazuhisa, Noda Masaki

Abstract excerpt

Tumor malignancy is associated with several features such as proliferation ability and frequency of metastasis. Since tumor metastasis shortens patients' lifetime, establishment of therapy for anti-metastasis is very important. Osteopontin (OPN), which abundantly expressed in bone matrix, is involved in cell adhesion, migration, extracellular matrix (ECM) invasion and cell proliferation via interaction with its...

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Identifiers

PMID: 17390343
DOI: 10.1002/jcb.21298

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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