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Role of osteopontin in the pathophysiology of cancer

21 Mar 2014

Abstract excerpt

Osteopontin (OPN) is a multifunctional cytokine that impacts cell proliferation, survival, drug resistance, invasion, and stem like behavior. Due to its critical involvement in regulating cellular functions, its aberrant expression and/or splicing is functionally responsible for undesirable alterations in disease pathologies, specifically cancer. It is implicated in promoting invasive and metastatic progression...

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PMID: 24657887
DOI: 10.1016/j.matbio.2014.03.001

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