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Article

The role of Osteopontin in tumor metastasis.

The Journal of surgical research - 1 Oct 2004

Wai Philip Y, Kuo Paul C

Abstract excerpt

Osteopontin (OPN) is a glyco-phosphoprotein that is expressed and secreted by numerous human cancers. OPN functions in cell adhesion, chemotaxis, macrophage-directed interleukin-10 (IL-10) suppression, stress-dependent angiogenesis, prevention of apoptosis, and anchorage-independent growth of tumor cells by regulating cell-matrix interactions and cellular signaling through binding with integrin and CD44...

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Extracellular Matrix
Molecular Structure
Neoplasm Metastasis
Neoplasms
Osteopontin
Receptors, Cell Surface

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sialoglycoproteins

Transcription, Genetic

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PMID: 15501463
DOI: 10.1016/j.jss.2004.03.028

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