Article
Extracellular and intracellular mechanisms that mediate the metastatic activity of exogenous osteopontin.
Cancer - 15 Apr 2009
Mandelin Jami, Lin Emme C K, Hu Dana D, Knowles Susan K, Do Kim-Anh, Wang Xuemei, Sage E Helene, Smith Jeffrey W, Arap Wadih, Pasqualini Renata
Abstract excerpt
BACKGROUND: Osteopontin affects several steps of the metastatic cascade. Despite direct correlation with metastasis in experimental systems and in patient studies, the extracellular and intracellular basis for these observations remains unsolved. In this study, the authors used human melanoma and sarcoma cell lines to evaluate the effects of soluble osteopontin on metastasis. METHODS: Exogenous osteopontin or...
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