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Article

Osteopontin mediates macrophage chemotaxis via α4 and α9 integrins and survival via the α4 integrin.

Journal of cellular biochemistry - 1 May 2013

Lund Susan Amanda, Wilson Carole L, Raines Elaine W, Tang Jingjing, Giachelli Cecilia M, Scatena Marta

Abstract excerpt

Osteopontin (OPN) is highly expressed by macrophages and plays a key role in the pathology of several chronic inflammatory diseases including atherosclerosis and the foreign body reaction. However, the molecular mechanism behind OPN regulation of macrophage functions is not well understood. OPN is a secreted molecule and interacts with several integrins via two domains: the RGD sequence binding to α(v)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23192608
DOI: 10.1002/jcb.24462

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