Article
Osteopontin is up-regulated and associated with neutrophil and macrophage infiltration in glioblastoma.
Immunology - 1 Jan 2011
Atai Nadia A, Bansal Manju, Lo Cheungh, Bosman Joost, Tigchelaar Wikky, Bosch Klazien S, Jonker Ard, De Witt Hamer Philip C, Troost Dirk, McCulloch Christopher A, Everts Vincent, Van Noorden Cornelis J F, Sodek Jaro
Abstract excerpt
Osteopontin (OPN) is a glycophosphoprotein with multiple intracellular and extracellular functions. In vitro, OPN enhances migration of mouse neutrophils and macrophages. In cancer, extracellular OPN facilitates migration of cancer cells via its RGD sequence. The present study was designed to investigate whether osteopontin is responsible for neutrophil and macrophage infiltration in human cancer and in...
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