Article
The RGD domain of human osteopontin promotes tumor growth and metastasis through activation of survival pathways.
PloS one - 10 Mar 2010
Courter Donald, Cao Hongbin, Kwok Shirley, Kong Christina, Banh Alice, Kuo Peiwen, Bouley Donna M, Vice Carmen, Brustugun Odd Terje, Denko Nicholas C, Koong Albert C, Giaccia Amato, Le Quynh-Thu
Abstract excerpt
BACKGROUND: Human osteopontin (OPN), a known tumor associated protein, exists in different isoforms, whose function is unclear. It also possesses a RGD domain, which has been implicated in diverse function. Here, we use genetic approaches to systematically investigate the function of the RGD domain in different OPN isoforms on tumor progression and metastasis for 2 different solid tumor models....
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