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Article

Efficient replication of human immunodeficiency virus type 1 requires a threshold level of Rev: potential implications for latency

1 Mar 1992

Abstract excerpt

The Rev protein of human immunodeficiency virus type 1 (HIV-1) is essential for the expression of the structural genes of HIV-1. To determine whether a functional threshold level of Rev is required to allow efficient HIV-1 replication, CD4-positive HeLa cells, constitutively expressing a Rev-deficient provirus, were transfected with various quantities of a Rev-expressing plasmid. Compared with the quantity of the...

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PMID: 1738210
DOI: 10.1128/jvi.66.3.1809-1813.1992

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Efficient replication of human immunodeficiency virus type 1 requires a threshold level of Rev: potential implications for latencyPMID 1738210Read ↗

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