Article
rasiRNAs, DNA damage, and embryonic axis specification.
Cold Spring Harbor symposia on quantitative biology - 1 Jan 2006
Theurkauf W E, Klattenhoff C, Bratu D P, McGinnis-Schultz N, Koppetsch B S, Cook H A
Abstract excerpt
Drosophila repeat-associated small interfering RNAs (rasiRNAs) have been implicated in retrotransposon and stellate locus silencing. However, mutations in the rasiRNA pathway genes armitage, spindle-E, and aubergine disrupt embryonic axis specification, triggering defects in microtubule organization and localization of osk and grk mRNAs during oogenesis. We show that mutations in mei-41 and mnk, which encode ATR...
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