Article
Altered dynein-dependent transport in piRNA pathway mutants.
Proceedings of the National Academy of Sciences of the United States of America - 16 Jun 2009
Navarro Caryn, Bullock Simon, Lehmann Ruth
Abstract excerpt
Maintenance of genome integrity in germ cells is crucial for the success of future generations. In Drosophila, and mammals, transposable element activity in the germline can cause DNA breakage and sterility. Recent studies have shown that proteins involved in piRNA (PIWI-interacting RNA) biogenesis are necessary for retrotransposon silencing in the Drosophila germline. Females mutant for genes in the piRNA...
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