Article
The Drosophila SDE3 homolog armitage is required for oskar mRNA silencing and embryonic axis specification.
Cell - 19 Mar 2004
Cook Heather A, Koppetsch Birgit S, Wu Jing, Theurkauf William E
Abstract excerpt
Polarization of the microtubule cytoskeleton during early oogenesis is required to specify the posterior of the Drosophila oocyte, which is essential for asymmetric mRNA localization during mid-oogenesis and for embryonic axis specification. The posterior determinant oskar mRNA is translationally silent until mid-oogenesis. We show that mutations in armitage and three components of the RNAi pathway disrupt oskar...
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