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Article

Drosophila rasiRNA pathway mutations disrupt embryonic axis specification through activation of an ATR/Chk2 DNA damage response.

Developmental cell - 1 Jan 2007

Klattenhoff Carla, Bratu Diana P, McGinnis-Schultz Nadine, Koppetsch Birgit S, Cook Heather A, Theurkauf William E

Abstract excerpt

Small repeat-associated siRNAs (rasiRNAs) mediate silencing of retrotransposons and the Stellate locus. Mutations in the Drosophila rasiRNA pathway genes armitage and aubergine disrupt embryonic axis specification, triggering defects in microtubule polarization as well as asymmetric localization of mRNA and protein determinants in the developing oocyte. Mutations in the ATR/Chk2 DNA damage signal transduction...

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PMID: 17199040
DOI: 10.1016/j.devcel.2006.12.001

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ATR

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