Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nuclear lamina dysfunction triggers a germline stem cell checkpoint.

Nature communications - 27 Sept 2018

Barton Lacy J, Duan Tingting, Ke Wenfan, Luttinger Amy, Lovander Kaylee E, Soshnev Alexey A, Geyer Pamela K

Abstract excerpt

LEM domain (LEM-D) proteins are conserved components of the nuclear lamina (NL) that contribute to stem cell maintenance through poorly understood mechanisms. The Drosophila emerin homolog Otefin (Ote) is required for maintenance of germline stem cells (GSCs) and gametogenesis. Here, we show that ote mutants carry germ cell-specific changes in nuclear architecture that are linked to GSC loss. Strikingly, we found...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle Checkpoints
Share to Checkpoint Kinase 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Damage

Share to DNA Transposable Elements

Share to Germ Cells

Share to Nuclear Lamina

Share to Oogenesis

Share to Stem Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 30262885
DOI: 10.1038/s41467-018-06277-z
PMCID: PMC6160405

Genes

GSC
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nuclear lamina dysfunction triggers a germline stem cell checkpoint.PMID 30262885Read ↗

Drosophila male and female germline stem cell niches require the nuclear lamina protein Otefin.Semantic proximity Read ↗

The Drosophila nuclear lamina protein otefin is required for germline stem cell survival.Semantic proximity Read ↗

Emerin preserves stem cell survival through maintenance of centrosome and nuclear lamina structure.Semantic proximity Read ↗

Otefin, a nuclear membrane protein, determines the fate of germline stem cells in Drosophila via interaction with Smad complexes.Semantic proximity Read ↗

A Surveillance Mechanism Ensures Repair of DNA Lesions during Zygotic ReprogrammingSemantic proximity Read ↗

Loss of GATA6 leads to nuclear deformation and aneuploidy in ovarian cancer.Semantic proximity Read ↗

Recruitment of BAF to the nuclear envelope couples the LINC complex to endoreplication.Semantic proximity Read ↗

Mitotic Nuclear Envelope Breakdown and Spindle Nucleation Are Controlled by Interphase Contacts between Centromeres and the Nuclear Envelope.Semantic proximity Read ↗

The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelopeSemantic proximity Read ↗

Unique and shared functions of nuclear lamina LEM domain proteins in Drosophila.Semantic proximity Read ↗

Mutational analyses of fs(1)Ya, an essential, developmentally regulated, nuclear envelope protein in Drosophila.Semantic proximity Read ↗

Expression of lamina proteins Lamin Dm0 and Kugelkern suppresses stem cell proliferationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.