Mutations in the insulator protein Suppressor of Hairy wing induce genome instability.

doi:10.1007/s00412-020-00743-8

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Article

Mutations in the insulator protein Suppressor of Hairy wing induce genome instability.

Chromosoma - 1 Dec 2020

Hsu Shih-Jui, Stow Emily C, Simmons James R, Wallace Heather A, Lopez Andrea Mancheno, Stroud Shannon, Labrador Mariano

Abstract excerpt

Insulator proteins orchestrate the three-dimensional organization of the genome. Insulators function by facilitating communications between regulatory sequences and gene promoters, allowing accurate gene transcription regulation during embryo development and cell differentiation. However, the role of insulator proteins beyond genome organization and transcription regulation remains unclear. Suppressor of Hairy...

Topics

Animals
Drosophila
Drosophila Proteins
Female
Genomic Instability
Genotype
Insulator Elements
Oogenesis
Ovary
Phenotype

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Open in PubMed

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PMID: 33140220
DOI: 10.1007/s00412-020-00743-8

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