Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

R2D2 organizes small regulatory RNA pathways in Drosophila.

Molecular and cellular biology - 1 Feb 2011

Okamura Katsutomo, Robine Nicolas, Liu Ying, Liu Qinghua, Lai Eric C

Abstract excerpt

Drosophila microRNAs (miRNAs) and small interfering RNAs (siRNAs) are generally produced by different Dicer enzymes (Dcr-1 and Dcr-2) and sorted to functionally distinct Argonaute effectors (AGO1 and AGO2). However, there is cross talk between these pathways, as highlighted by the recognition that Drosophila miRNA* strands (the partner strands of mature miRNAs) are generated by Dcr-1 but are preferentially sorted...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Argonaute Proteins
Share to Base Pair Mismatch
Share to Eukaryotic Initiation Factors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Insect

Share to Nucleic Acid Heteroduplexes

Share to Ribonuclease III

Share to RNA Helicases

Share to RNA-Induced Silencing Complex

Source

Open in PubMed Open full text

Identifiers

PMID: 21135122
DOI: 10.1128/MCB.01141-10
PMCID: PMC3028645

Genes

AGO1
AGO2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

R2D2 organizes small regulatory RNA pathways in Drosophila.PMID 21135122Read ↗

R2D2, a bridge between the initiation and effector steps of the Drosophila RNAi pathway.Semantic proximity Read ↗

Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways.Semantic proximity Read ↗

The C-terminal dsRNA-binding domain of Drosophila Dicer-2 is crucial for efficient and high-fidelity production of siRNA and loading of siRNA to Argonaute2.Semantic proximity Read ↗

The RNAi pathway initiated by Dicer-2 in Drosophila.Semantic proximity Read ↗

Conversion of pre-RISC to holo-RISC by Ago2 during assembly of RNAi complexes.Semantic proximity Read ↗

Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes.Semantic proximity Read ↗

Functional analysis of dicer-2 missense mutations in the siRNA pathway of Drosophila.Semantic proximity Read ↗

Roles for Drosophila cap1 2'-O-ribose methyltransferase in the small RNA silencing pathway associated with Argonaute 2.Semantic proximity Read ↗

Mutational analysis of Aedes aegypti Dicer 2 provides insights into the biogenesis of antiviral exogenous small interfering RNAsSemantic proximity Read ↗

Transposon defense by endo-siRNAs, piRNAs and somatic pilRNAs in Drosophila: contributions of Loqs-PD and R2D2.Semantic proximity Read ↗

The mechanism of DRB7.2:DRB4 mediated sequestering of endogenous inverted-repeat dsRNA precursors in plantsSemantic proximity Read ↗

Drosophila R2D2 mediates follicle formation in somatic tissues through interactions with Dicer-1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.