Incorporating single-locus tests into haplotype cladistic analysis in case-control studies.

doi:10.1371/journal.pgen.0030046

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Article

Incorporating single-locus tests into haplotype cladistic analysis in case-control studies.

PLoS genetics - 23 Mar 2007

Liu Jianfeng, Papasian Chris, Deng Hong-Wen

Abstract excerpt

In case-control studies, genetic associations for complex diseases may be probed either with single-locus tests or with haplotype-based tests. Although there are different views on the relative merits and preferences of the two test strategies, haplotype-based analyses are generally believed to be more powerful to detect genes with modest effects. However, a main drawback of haplotype-based association tests is...

Topics

Algorithms
Alleles
Arthritis, Rheumatoid
Bayes Theorem
Case-Control Studies
Cluster Analysis
Computer Simulation
False Positive Reactions
Gene Frequency
Genetic Markers
Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genome, Human

Genotype

Haplotypes

Heterozygote

Humans

Likelihood Functions

Linkage Disequilibrium

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Identifiers

PMID: 17381242
DOI: 10.1371/journal.pgen.0030046
PMCID: PMC1829402

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