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Article

Efficient unified rare variant association test by modeling the population genetic distribution in case-control studies.

Genetic epidemiology - 1 Nov 2016

Li Huilin, Chen Jinbo

Abstract excerpt

Recent advancements in next-generation DNA sequencing technologies have made it plausible to study the association of rare variants with complex diseases. Due to the low frequency, rare variants need to be aggregated in association tests to achieve adequate power with reasonable sample sizes. Hierarchical modeling/kernel machine methods have gained popularity among many available methods for testing a set of rare...

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Identifiers

PMID: 27550412
DOI: 10.1002/gepi.21995
PMCID: PMC5069155

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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