Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Linkage disequilibrium mapping via cladistic analysis of single-nucleotide polymorphism haplotypes.

American journal of human genetics - 1 Jul 2004

Durrant Caroline, Zondervan Krina T, Cardon Lon R, Hunt Sarah, Deloukas Panos, Morris Andrew P

Abstract excerpt

We present a novel approach to disease-gene mapping via cladistic analysis of single-nucleotide polymorphism (SNP) haplotypes obtained from large-scale, population-based association studies, applicable to whole-genome screens, candidate-gene studies, or fine-scale mapping. Clades of haplotypes are tested for association with disease, exploiting the expected similarity of chromosomes with recent shared ancestry in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Mapping
Share to Computer Simulation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetics, Population

Share to Haplotypes

Share to Linkage Disequilibrium

Share to Models, Genetic

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 15148658
DOI: 10.1086/422174
PMCID: PMC1182006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Linkage disequilibrium mapping via cladistic analysis of single-nucleotide polymorphism haplotypes.PMID 15148658Read ↗

Association mapping via regularized regression analysis of single-nucleotide-polymorphism haplotypes in variable-sized sliding windows.Semantic proximity Read ↗

Association mapping by generalized linear regression with density-based haplotype clustering.Semantic proximity Read ↗

Coalescent methods for fine-scale disease-gene mapping.Semantic proximity Read ↗

The effect of single nucleotide polymorphism identification strategies on estimates of linkage disequilibrium.Semantic proximity Read ↗

A flexible Bayesian framework for modeling haplotype association with disease, allowing for dominance effects of the underlying causative variants.Semantic proximity Read ↗

Linkage disequilibrium maps and disease-association mapping.Semantic proximity Read ↗

Haplotype-based linkage disequilibrium mapping via direct data mining.Semantic proximity Read ↗

Incorporating single-locus tests into haplotype cladistic analysis in case-control studies.Semantic proximity Read ↗

Fine-scale structure of the genome and markers used in association mapping.Semantic proximity Read ↗

Family-based association tests for genomewide association scans.Semantic proximity Read ↗

SeqSIMLA: a sequence and phenotype simulation tool for complex disease studies.Semantic proximity Read ↗

Genome-wide linkage disequilibrium and haplotype maps.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.