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Article

Linkage disequilibrium mapping via cladistic analysis of single-nucleotide polymorphism haplotypes.

American journal of human genetics - 1 Jul 2004

Durrant Caroline, Zondervan Krina T, Cardon Lon R, Hunt Sarah, Deloukas Panos, Morris Andrew P

Abstract excerpt

We present a novel approach to disease-gene mapping via cladistic analysis of single-nucleotide polymorphism (SNP) haplotypes obtained from large-scale, population-based association studies, applicable to whole-genome screens, candidate-gene studies, or fine-scale mapping. Clades of haplotypes are tested for association with disease, exploiting the expected similarity of chromosomes with recent shared ancestry in...

Topics

Chromosome Mapping
Computer Simulation
Genetics, Population
Haplotypes
Humans
Linkage Disequilibrium
Models, Genetic
Polymorphism, Single Nucleotide

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15148658
DOI: 10.1086/422174
PMCID: PMC1182006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-15148658-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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