Haplotype kernel association test as a powerful method to identify chromosomal regions harboring uncommon causal variants.

Abstract excerpt

For most complex diseases, the fraction of heritability that can be explained by the variants discovered from genome-wide association studies is minor. Although the so-called "rare variants" (minor allele frequency [MAF] < 1%) have attracted increasing attention, they are unlikely to account for much of the "missing heritability" because very few people may carry these rare variants. The genetic variants that are...

Topics

• Adiposity
• Body Mass Index
• Chromosomes, Human
• Computer Simulation
• Gene Frequency
• Genetic Variation
• Genetics, Population
• Genotype
• Haplotypes
• Humans
• Janus Kinase 2