Article
Genome-wide association filtering using a highly locus-specific transmission/disequilibrium test.
Human genetics - 1 Sept 2010
Abad-Grau María M, Medina-Medina Nuria, Montes-Soldado Rosana, Moreno-Ortega José, Matesanz Fuencisla
Abstract excerpt
Multimarker transmission/disequilibrium tests (TDTs) are powerful association and linkage tests used to perform genome-wide filtering in the search for disease susceptibility loci. In contrast to case/control studies, they have a low rate of false positives for population stratification and admixture. However, the length of a region found in association with a disease is usually very large because of linkage...
Topics
- Biostatistics
- Databases, Genetic
- Female
- Genetic Markers
- Genetic Predisposition to Disease
- Genetics, Population
- Genome-Wide Association Study
- Haplotypes
- Humans
- Linkage Disequilibrium
- Male
- Models, Genetic
- Oligonucleotide Array Sequence Analysis
- Polymorphism, Single Nucleotide