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Article

Microsomal epoxide hydrolase genotype and risk of myocardial infarction.

Archives of toxicology - 1 Sept 2007

Cornelis Marilyn C, El-Sohemy Ahmed, Campos Hannia

Abstract excerpt

DNA damage caused by mutagens found in tobacco smoke may contribute to the development of coronary heart disease (CHD). Microsomal epoxide hydrolase (EPHX1) is involved in the metabolism of tobacco smoke mutagens and an amino acid substitution (H139R) in exon 4 of the EPHX1 gene is associated with increased enzyme activity. The objective of this study was to investigate the effect of EPHX1 genotype on risk of...

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Source

Identifiers

PMID: 17380322
DOI: 10.1007/s00204-007-0198-1

Genes

EPHX1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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