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Article

Genetically lowered microsomal epoxide hydrolase activity and tobacco-related cancer in 47,000 individuals.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Aug 2011

Lee Julie, Dahl Morten, Nordestgaard Børge G

Abstract excerpt

BACKGROUND: Two functional polymorphisms of the microsomal epoxide hydrolase (mEH) gene (EPHX1), Tyr113His (rs1051740) and His139Arg (rs2234922), have variably been found to influence susceptibility to various cancer forms. We tested whether genetically lowered mEH activity affects risk of developing cancer in the general population. METHODS: We genotyped 47,089 individuals from the Danish general population for...

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Identifiers

PMID: 21653646
DOI: 10.1158/1055-9965.EPI-10-1165

Genes

EPHX1
IMPACT

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