Article
Microsomal epoxide hydrolase polymorphisms, cigarette smoking, and risk of colorectal cancer: the Fukuoka Colorectal Cancer Study.
Molecular carcinogenesis - 1 Aug 2013
Nisa Hoirun, Budhathoki Sanjeev, Morita Makiko, Toyomura Kengo, Nagano Jun, Ohnaka Keizo, Kono Suminori, Ueki Takashi, Tanaka Masao, Kakeji Yoshihiro, Maehara Yoshihiko, Okamura Takeshi, Ikejiri Koji, Futami Kitaroh, Maekawa Takafumi, Yasunami Yohichi, Takenaka Kenji, Ichimiya Hitoshi, Terasaka Reiji
Abstract excerpt
Microsomal epoxide hydrolase (EPHX1) plays an important role in the activation and detoxification of polycyclic aromatic hydrocarbons, carcinogens found in cigarette smoke. Polymorphisms in exon 3 (Y113H) and exon 4 (H139R) of the EPHX1 have been associated with enzyme activity. We investigated the risk of colorectal cancer in relation to the EPHX1 Y113H and H139R polymorphisms and assessed effect modifications...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.