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Article

Association between head and neck cancer and microsomal epoxide hydrolase genotypes.

Archives of toxicology - 1 Jan 2003

Wenghoefer Matthias, Pesch Beate, Harth Volker, Broede Peter, Fronhoffs Stefan, Landt Olfert, Brüning Thomas, Abel Josef, Bolt Hermann M, Herberhold Claus, Vetter Hans, Ko Yon-Dschun

Abstract excerpt

Tobacco-associated carcinogens are catalyzed by microsomal epoxide hydrolase (mEH). Combinations of the Y113H and H139R polymorphic EPHX1 variants have been assumed to alter the enzyme activity and thus the risk of squamous cell head and neck cancer (SCCHN). Based on in vitro data, a putative low, medium and high mEH activity has been associated with combinations of these genotypes, and the respective activity...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12491039
DOI: 10.1007/s00204-002-0414-y

Genes

EPHX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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