High-activity microsomal epoxide hydrolase genotypes and the risk of oral, pharynx, and larynx cancers.

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Article

High-activity microsomal epoxide hydrolase genotypes and the risk of oral, pharynx, and larynx cancers.

Cancer research - 1 Feb 2000

Jourenkova-Mironova N, Mitrunen K, Bouchardy C, Dayer P, Benhamou S, Hirvonen A

Abstract excerpt

Human microsomal epoxide hydrolase (mEH), encoded by the EPHX1 gene, is involved in the metabolism of tobacco carcinogens. We investigated the effect of exon 3 and 4 polymorphisms of the EPHX1 gene in 121 patients with cancers of the oral cavity/pharynx, 129 patients with cancer of the larynx, and 172 non-cancer controls, all Caucasian regular smokers. The potential modifying role of previously analyzed GSTM1,...

Topics

Adult
Aged
Aged, 80 and over
Epoxide Hydrolases
Female
Genotype
Glutathione Transferase
Humans
Laryngeal Neoplasms
Male
Microsomes
Middle Aged
Mouth Neoplasms
Pharyngeal Neoplasms

Source

Open in PubMed

Identifiers

PMID: 10676631

Genes

EPHX1
GSTM3
GSTM1
GSTP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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