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Article

Preproenkephalin knockout mice show no depression-related phenotype.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Nov 2007

Bilkei-Gorzo Andras, Michel Kerstin, Noble Florence, Roques Bernard P, Zimmer Andreas

Abstract excerpt

Clinical, preclinical, and pharmacological studies have suggested that decreased enkephalin tone is associated with depression-like symptoms and increase in enkephalin signaling could have a therapeutic value in the treatment of depression. In this study we demonstrate that, surprisingly, animals...

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PMID: 17375141
DOI: 10.1038/sj.npp.1301370

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17375141-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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