Article
Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses.
Nature genetics - 1 Jun 2000
Filliol D, Ghozland S, Chluba J, Martin M, Matthes H W, Simonin F, Befort K, Gavériaux-Ruff C, Dierich A, LeMeur M, Valverde O, Maldonado R, Kieffer B L
Abstract excerpt
The role of the opioid system in controlling pain, reward and addiction is well established, but its role in regulating other emotional responses is poorly documented in pharmacology. The mu-, delta- and kappa- opioid receptors (encoded by Oprm, Oprd1 and Oprk1, respectively) mediate the biological activity of opioids. We have generated Oprd1-deficient mice and compared the behavioural responses of mice lacking...
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