Article
Comparison of the phenotype of NK1R-/- mice with pharmacological blockade of the substance P (NK1 ) receptor in assays for antidepressant and anxiolytic drugs.
Behavioural pharmacology - 1 Nov 2001
Rupniak N M, Carlson E J, Webb J K, Harrison T, Porsolt R D, Roux S, de Felipe C, Hunt S P, Oates B, Wheeldon A
Abstract excerpt
The phenotype of NK1R-/- mice was compared with that of acute pharmacological blockade of the tachykinin NK1 receptor on sensorimotor function and in assays relevant to depressive illness and anxiety. The dose range for L-760735 and GR205171 that was associated with functional blockade of central NK1 receptors in the target species was established by antagonism of the behavioural effects of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.