Article
Behavioral phenotype of pre-proenkephalin-deficient mice on diverse congenic backgrounds.
Psychopharmacology - 1 Nov 2004
Bilkei-Gorzo Andras, Racz Ildiko, Michel Kerstin, Zimmer Anne, Klingmüller Dietrich, Zimmer Andreas
Abstract excerpt
RATIONALE: The phenotype of genetically modified animals is thought to result from an interaction of gene manipulation with the genetic background and environmental factors. OBJECTIVES: To test the behavioral and drug responses of Penk1(-/-) mice on different genetic backgrounds. METHODS: Congenic C57BL/6J and DBA/2J mouse strains with a targeted deletion of the Penk1 gene were generated. Behavior and drug...
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