Article
Menin Reduces Parvalbumin Expression and is Required for the Anti-Depressant Function of Ketamine.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Feb 2024
Leng Lige, Zhuang Kai, Lin Hui, Ding Jinjun, Yang Shangchen, Yuan Ziqi, Huang Changquan, Chen Guimiao, Chen Zhenlei, Wang Mengdan, Wang Han, Sun Hao, Li Huifang, Chang He, Chen Zhenyi, Xu Qi, Yuan Tifei, Zhang Jie
Abstract excerpt
Dysfunction of parvalbumin (PV) neurons is closely involved in depression, however, the detailed mechanism remains unclear. Based on the previous finding that multiple endocrine neoplasia type 1 (Protein: Menin; Gene: Men1) mutation (G503D) is associated with a higher risk of depression, a Menin-G503D mouse model is generated that exhibits heritable depressive-like phenotypes and increases PV expression in brain....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.