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Article

Mouse anxiety: the power of knockout.

The pharmacogenomics journal - 1 Jan 2001

Lesch K P

Abstract excerpt

The role of the neurokinine 1 receptors (NK1R) and its endogenous ligand, the neuropeptide substance P (SP) in the pathophysiology and treatment response of anxiety and depression has been controversial. In a new study, however, mice with a targeted inactivation of the NK1R show a phenotype that is associated with anxiety-related behaviors and stress responses. Since this behavioral phenotype was associated with...

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Identifiers

PMID: 11908755
DOI: 10.1038/sj.tpj.6500016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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