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Article

Generation of two homozygous SHOX2 knock-out human induced pluripotent stem cell lines using CRISPR/Cas9.

Stem cell research - 1 Jun 2023

Rädecke Kristin, Gore Ambuj, Burau Karin, Laugsch Magdalena, Köhler Katrin, Rappold Gudrun A, Hoffmann Sandra

Abstract excerpt

SHOX2 is a homeobox transcription factor associated with atrial fibrillation (AF) and sinus node dysfunction. Here, we generated two homozygous SHOX2 knock-out hiPSC lines from a healthy control line and a corrected AF patient line (disease-specific SHOX2 mutation corrected to WT) using CRISPR/Cas9. These cell lines maintained pluripotency, an ability to differentiate into all three germlayers and a normal...

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Identifiers

PMID: 37028180
DOI: 10.1016/j.scr.2023.103089

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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