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Article

Coding and non-coding variants in the SHOX2 gene in patients with early-onset atrial fibrillation.

Basic research in cardiology - 1 May 2016

Hoffmann Sandra, Clauss Sebastian, Berger Ina M, Weiß Birgit, Montalbano Antonino, Röth Ralph, Bucher Madeline, Klier Ina, Wakili Reza, Seitz Hervé, Schulze-Bahr Eric, Katus Hugo A, Flachsbart Friederike, Nebel Almut, Guenther Sabina Pw, Bagaev Erik, Rottbauer Wolfgang, Kääb Stefan, Just Steffen, Rappold Gudrun A

Abstract excerpt

Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia with a strong genetic component. Molecular pathways involving the homeodomain transcription factor Shox2 control the development and function of the cardiac conduction system in mouse and zebrafish. Here we report the analysis of human SHOX2 as a potential susceptibility gene for early-onset AF. To identify causal variants and define the underlying...

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Source

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Identifiers

PMID: 27138930
DOI: 10.1007/s00395-016-0557-2
PMCID: PMC4853439

Genes

SHOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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