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Article

Age-related changes in echocardiographic measurements: association with variation in the estrogen receptor-alpha gene.

Hypertension (Dallas, Tex. : 1979) - 1 May 2007

Peter Inga, Huggins Gordon S, Shearman Amanda M, Pollak Arthur, Schmid Christopher H, Cupples L Adrienne, Demissie Serkalem, Patten Richard D, Karas Richard H, Housman David E, Mendelsohn Michael E, Vasan Ramachandran S, Benjamin Emelia J

Abstract excerpt

Left ventricular (LV) mass and other LV measures have been shown to be heritable. In this study we hypothesized that functional variation in the gene coding for estrogen receptor-alpha (ESR1), known for mediating the effect of estrogens on myocardium, is associated with age-related changes in LV structure. Four genetic markers (ESR1 TA repeat; rs2077647, or +30T>C; rs2234693, or PvuII; and rs9340799, or XbaI)...

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Source

Identifiers

PMID: 17372038
DOI: 10.1161/HYPERTENSIONAHA.106.083790

Genes

ESR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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