Article
Sex-specific differences in the genetic and environmental effects on cardiac phenotypic variation assessed by echocardiography.
Scientific reports - 8 Apr 2023
Lin Honghuang, Kwan Alan C, Castro-Diehl Cecilia, Short Meghan I, Xanthakis Vanessa, Yola Ibrahim M, Salto Gerran, Mitchell Gary F, Larson Martin G, Vasan Ramachandran S, Cheng Susan
Abstract excerpt
The drivers of sexual dimorphism in heart failure phenotypes are currently poorly understood. Divergent phenotypes may result from differences in heritability and genetic versus environmental influences on the interplay of cardiac structure and function. To assess sex-specific heritability and genetic versus environmental contributions to variation and inter-relations between echocardiography traits in a large...
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