Article
Association of estrogen receptor beta gene polymorphisms with left ventricular mass and wall thickness in women.
American journal of hypertension - 1 Nov 2005
Peter Inga, Shearman Amanda M, Vasan Ramachandran S, Zucker Deborah R, Schmid Christopher H, Demissie Serkalem, Cupples L Adrienne, Kuvin Jeffrey T, Karas Richard H, Mendelsohn Michael E, Housman David E, Benjamin Emelia J
Abstract excerpt
BACKGROUND: Left ventricular (LV) hypertrophy is a significant risk factor for cardiovascular disease. Given sex-based differences in cardiac structure and remodeling, we hypothesized that variation in estrogen pathway genes might be associated with alteration of LV structure. METHODS: We studied 1249 unrelated individuals, 547 men and 702 women (mean age 59 years) from the Framingham Heart Study. Eight single...
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