Article
Estrogen receptor alpha gene variation is associated with risk of myocardial infarction in more than seven thousand men from five cohorts.
Circulation research - 17 Mar 2006
Shearman Amanda M, Cooper Jackie A, Kotwinski Paul J, Miller George J, Humphries Steve E, Ardlie Kristin G, Jordan Barbara, Irenze Kathryn, Lunetta Kathryn L, Schuit Stephanie C E, Uitterlinden André G, Pols Huibert A P, Demissie Serkalem, Cupples L Adrienne, Mendelsohn Michael E, Levy Daniel, Housman David E
Abstract excerpt
Understanding the mechanisms by which estrogens affect cardiovascular disease risk, including the role of variation in the gene for estrogen receptor alpha (ESR1), may be key to new treatment strategies. We investigated whether the CC genotype at ESR1 c.454-397T>C is associated with increased risk among men. Study of more than 7000 whites in 5 cohorts from 4 countries provided evidence that genotype CC, present...
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