Article
Polymorphisms in the estrogen receptor alpha gene and endothelial function in resistance and conduit arteries in the elderly.
Atherosclerosis - 1 Jul 2008
Ingelsson Erik, Syvänen Ann-Christine, Lind Lars
Abstract excerpt
BACKGROUND: Prior evidence suggests an important role for estrogen in the regulation of endothelium-dependent vasodilation, but the mechanisms modulating this are not known. Our aim was to examine the relations of single nucleotide polymorphisms (SNPs) in the estrogen receptor alpha gene (ESR1) to endothelium-dependent vasodilation. METHODS: We evaluated 959 70-year-old participants (51% men) of the Prospective...
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