Left ventricular structure and function in relation to steroid biosynthesis genes in a white population.

doi:10.1038/ajh.2012.69

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Article

Left ventricular structure and function in relation to steroid biosynthesis genes in a white population.

American journal of hypertension - 1 Sept 2012

Jin Yu, Kuznetsova Tatiana, Citterio Lorena, Thijs Lutgarde, Messaggio Elisabetta, Casamassima Nunzia, Manunta Paolo, Fagard Robert, Bianchi Giuseppe, Staessen Jan A

Abstract excerpt

BACKGROUND: Both endogenous ouabain (EO) and aldosterone are steroid hormones which might play a role in the pathogenesis of left ventricular (LV) hypertrophy and cardiac remodeling. Cholesterol side-chain cleavage enzyme (CYP11A1) and 3β-hydroxysteroid dehydrogenase (HSD3B1) are two key enzymes in the pathway of steroid biosynthesis. METHODS: We investigated in 532 individuals (mean age, 50.3 years; 51.5% women)...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Cholesterol Side-Chain Cleavage Enzyme
Female
Heart Ventricles
Humans
Male
Middle Aged
Multienzyme Complexes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Progesterone Reductase

Steroid Isomerases

Ultrasonography

Ventricular Function, Left

White People

Source

Open in PubMed

Identifiers

PMID: 22673022
DOI: 10.1038/ajh.2012.69

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