Article
Estrogen receptor genotype modulates myocardial perfusion in young men.
Journal of molecular medicine (Berlin, Germany) - 1 Dec 2004
Kunnas Tarja A, Lehtimäki Terho, Karhunen Pekka J, Laaksonen Reijo, Janatuinen Tuula, Vesalainen Risto, Nuutila Pirjo, Knuuti Juhani, Nikkari Seppo T
Abstract excerpt
Most of the effects of estrogens are mediated by estrogen receptors. Vascular endothelial cells and smooth muscle cells express estrogen receptor alpha (ESR1) in both genders. A long genotype group of a common thymine-adenine (TA) dinucleotide repeat polymorphism in the regulatory region of this gene has previously been related to coronary artery disease. The present study examined whether coronary blood flow is...
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