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Article

Association between estrogen receptor alpha gene variation and cardiovascular disease.

JAMA - 5 Nov 2003

Shearman Amanda M, Cupples L Adrienne, Demissie Serkalem, Peter Inga, Schmid Christopher H, Karas Richard H, Mendelsohn Michael E, Housman David E, Levy Daniel

Abstract excerpt

CONTEXT: Estrogen and related hormone therapies activate estrogen receptors, which in turn regulate genes for several cardiovascular disease (CVD) risk factors. Relatively little is known, however, about the impact of genetic variation in estrogen receptor alpha (ESR1) on CVD risk. OBJECTIVE: To investigate whether the ESR1 c.454-397T>C polymorphism is associated with CVD risk. DESIGN, SETTING, AND PARTICIPANTS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Genetic

Share to Receptors, Estrogen

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Source

Identifiers

PMID: 14600184
DOI: 10.1001/jama.290.17.2263

Genes

ESR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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