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Article

Estrogen receptor alpha gene polymorphisms and risk of myocardial infarction.

JAMA - 23 Jun 2004

Schuit Stephanie C E, Oei Hok-Hay S, Witteman Jacqueline C M, Geurts van Kessel Corine H, van Meurs Joyce B J, Nijhuis Rogier L, van Leeuwen Johannes P T M, de Jong Frank H, Zillikens M Carola, Hofman Albert, Pols Huibert A P, Uitterlinden André G

Abstract excerpt

CONTEXT: The role of estrogens in ischemic heart disease (IHD) is uncertain. Evidence suggests that genetic variations in the estrogen receptor alpha (ESR1) gene may influence IHD risk, but the role of common sequence variations in the ESR1 gene is unclear. OBJECTIVE: To determine whether the ESR1 haplotype created by the c.454-397T>C (PvuII) and c.454-351A>G (XbaI) polymorphisms is associated with myocardial...

Topics

Aged
Estrogen Receptor alpha
Female
Genotype
Haplotypes
Humans
Male
Middle Aged
Myocardial Infarction
Myocardial Ischemia
Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Postmenopause

Proportional Hazards Models

Prospective Studies

Receptors, Estrogen

Risk Factors

Source

Identifiers

PMID: 15213208
DOI: 10.1001/jama.291.24.2969

Genes

ESR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Estrogen receptor alpha gene polymorphisms and risk of myocardial infarction.PMID 15213208Read ↗

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