Article
DNMT1 modulates gene expression without its catalytic activity partially through its interactions with histone-modifying enzymes.
Nucleic acids research - 1 May 2012
Clements Eriko G, Mohammad Helai P, Leadem Benjamin R, Easwaran Hariharan, Cai Yi, Van Neste Leander, Baylin Stephen B
Abstract excerpt
While DNA methyltransferase1 (DNMT1) is classically known for its functions as a maintenance methyltransferase enzyme, additional roles for DNMT1 in gene expression are not as clearly understood. Several groups have shown that deletion of the catalytic domain from DNMT1 does not abolish repressive activity of the protein against a reporter gene. In our studies, we examine the repressor function of catalytically...
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