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Article

Major and essential role for the DNA methylation mark in mouse embryogenesis and stable association of DNMT1 with newly replicated regions.

Molecular and cellular biology - 1 Dec 2007

Takebayashi Shin-ichiro, Tamura Takashi, Matsuoka Chisa, Okano Masaki

Abstract excerpt

DNA methyltransferase 1 (DNMT1) plays an important role in the inheritance of genomic DNA methylation, which is coupled to the DNA replication process. Early embryonic lethality in DNMT1-null mutant (Dnmt1(c)) mice indicates that DNA methylation is essential for mammalian development. DNMT1, however, interacts with a number of transcriptional regulators and has a transcriptional repressor activity independent of...

Topics

Alleles
Animals
Catalysis
Catalytic Domain
Cell Proliferation
Crosses, Genetic
DNA (Cytosine-5-)-Methyltransferase 1
DNA (Cytosine-5-)-Methyltransferases
DNA Methylation
DNA Replication

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Embryo Loss

Embryo, Mammalian

Embryonic Development

Embryonic Stem Cells

Female

Genome

Genotype

Heterochromatin

Source

Open in PubMed Open full text

Identifiers

PMID: 17893328
DOI: 10.1128/MCB.00899-07
PMCID: PMC2169176

Genes

DNMT1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Major and essential role for the DNA methylation mark in mouse embryogenesis and stable association of DNMT1 with newly replicated regions.PMID 17893328Read ↗

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